研究・業績

Achievements　＆　Research

研究内容

研究内容１
研究内容２
研究内容３
研究内容4
研究内容5

研究業績

2025

1: Suppressive Effects of Kouboku on Methyl Mercaptan Production and Biofilm Formation in Porphyromonas gingivalis.
Taniguchi Y, Ouhara K, Sato Y, Shoji M, Hou Y, Zhai R, Fujimori R, Kuwahara N, Tamura T, Matsuda S, Mizuno N.
Yuri Taniguchi and Kazuhisa Ouhara contributed equally.
Mol Oral Microbiol. 2025 Jun;40(3):128-136. (IF=3.56; Q2)

2024

1. Periodontal Treatment During the Blanking Period Improves the Outcome of Atrial Fibrillation Ablation.
Miyauchi S, Ouhara K, Shintani T, Tokuyama T, Okubo Y, Okamura S, Miyamoto S, Oguri N, Uotani Y, Takemura T, Tari M, Hiyama T, Miyauchi M, Kajiya M, Mizuno N, Nakano Y.
J Am Heart Assoc. 2024 Apr 16;13(8) （IF＝5.4）
2. Predictive factors of periodontal regeneration outcomes using rhFGF-2: A case-control study.
Matsuda S, Ueda T, Nakashima F, Ninomiya Y, Yasuda K, Sasaki S, Hamamoto Y, Iwata T, Ouhara K, Mihara N, Kakimoto N, Mizuno N.
J Periodontal Res. 2024 Mar 25. （IF＝3.5）
3. Periodontal tissue regeneration with cementogenesis after application of brain-derived neurotrophic factor in 3-wall inflamed intra-bony defect.
Kiyota M, Iwata T, Hasegawa N, Sasaki S, Taniguchi Y, Hamamoto Y, Matsuda S, Ouhara K, Takeda K, Fujita T, Kurihara H, Kawaguchi H, Mizuno N. J Periodontal Res. 2024 Mar 19. (IF=3.5)
4. Periostin regulates integrin expression in gingival epithelial cells.
Hirata R, Iwata T, Fujita T, Nagahara T, Matsuda S, Sasaki S, Taniguchi Y, Hamamoto Y, Ouhara K, Kudo Y, Kurihara H, Mizuno N.
J Oral Biosci. 2024 Mar;66(1):170-178. （IF=2.4）
5. Effect of Periodontal Treatment on Reducing Chronic Inflammation in Systemically Healthy Patients With Periodontal Disease.
Matsuda S, Shintani T, Miyagawa T, Yumoto H, Komatsu Y, Dewake N, Iwata T, Nagano T, Morozumi T, Goto R, Kato S, Kitamura M, Shin K, Sekino S, Yamashita A, Yamashita K, Yoshimura A, Sugaya T, Takashiba S, Taguchi Y, Nemoto E, Nishi H, Mizuno N, Numabe Y, Kawaguchi H.
Am J Med. 2024 Mar;137(3):273-279. （IF=5.9）
6. Loss-of-function OGFRL1 variants identified in autosomal recessive cherubism families.
Kittaka M, Mizuno N, Morino H, Yoshimoto T, Zhu T, Liu S, Wang Z, Mayahara K, Iio K, Kondo K, Kondo T, Hayashi T, Coghlan S, Teno Y, Doan AAP, Levitan M, Choi RB, Matsuda S, Ouhara K, Wan J, Cassidy AM, Pelletier S, Nampoothiri S, Urtizberea AJ, Robling AG, Ono M, Kawakami H, Reichenberger EJ, Ueki Y.
JBMR Plus. 2024 Apr 9;8(6):ziae050. （IF＝3.8）
7. Leucine-rich alpha-2-glycoprotein 1 affects bone destruction via IL-6 in mouse periodontitis model.
Ouhara K, Takemura T, Taniguchi Y, Fujimori R, Tamura T, Akane Y, Matsuda S, Hamamoto Y, Shintani T, Kajiya M, Munenaga S, Iwata T, Fujita T, Mizuno N.
Oral Dis. 2024 Apr 24. （IF＝3.8）
8. Nuclear receptor 4A1 (NR4A1) upregulated by n-butylidenephthalide via the mitogen-activated protein kinase (MAPK) pathway ameliorates drug-induced gingival enlargement.
Ueda T, Matsuda S, Ninomiya Y, Nakashima F, Yasuda K, Furutama D, Memida T, Yoshimoto T, Kajiya M, Ohta K, Ouhara K, Mizuno N.
Biofactors. 2024 May 22. （IF＝5.0）
9. Role of sclerostin deletion in bisphosphonate-induced osteonecrosis of the jaw.
Nakashima F, Matsuda S, Ninomiya Y, Ueda T, Yasuda K, Hatano S, Shimada S, Furutama D, Memida T, Kajiya M, Shukunami C, Ouhara K, Mizuno N. Bone. 2024 Jul 15;187:117200. （IF＝3.5）
10. Role of transglutaminase 2 in promoting biglycan synthesis in idiopathic gingival　fibromatosis. BMC Oral Health. 2024 Nov 21;24(1):1422. （IF=2.6）
Ninomiya Y, Matsuda S, Suzuki S, Hirata-Tsuchiya S, Ueda T, Nakashima F,　Yasuda K, Shimada S, Memida T, Yoshimoto T, Yamada S, Ouhara K, Mizuno N.
11. Brain-derived neurotrophic factor promotes bone regeneration in a canine model of peri-implantitis. Int J Implant Dent. 2024 Nov 26;10(1):59. （IF=3.1）
Kono S, Sasaki S, Matsuda S, Takeda K, Iwata T, Ouhara K, Kajiya M, Kurihara　H, Mizuno N.
12. Oral administration of Porphyromonas gingivalis to mice with diet-induced obesity impairs cognitive function associated with microglial activation in the brain.
Oue K, Yamawaki Y, Ouhara K, Imado E, Tamura T, Doi M, Shimizu Y, Yoshida M, Mizuno N, Morioka N, Kanematsu T, Irifune M, Ago Y.
J Oral Microbiol. 2024 Nov 14 (IF=3.94)
13. The oral cavity is a potential reservoir of gram-negative
antimicrobial-resistant bacteria, which are correlated with ageing and the number of teeth.
Kawayanagi T, Kawada-Matsuo M, Takeshita T, Nguyen-Tra Le M, Asakawa M, Sugawara Y, Arai C, Ouhara K, Nishi H, Mizuno N, Kawaguchi H, Shiba H, Sugai M, Komatsuzawa H.
Heliyon. 2024 Oct 28 (IF=1.86)
14. Saving a hopeless tooth with a four-wall bone defect: A case report.
Nagahara T, Iwata T, Wada K, Ueda T, Kono S, Ouhara K, Mizuno N.
Clin Adv Periodontics. 2024 Dec 23 (IF=0.25)

2023

1. Relationship Between Periodontitis and Atrial Fibrosis in Atrial Fibrillation:Histological Evaluation of Left Atrial Appendages
Miyauchi S, Nishi H, Ouhara K, Tokuyama T, Okubo Y,Okamura S, Miyamoto S, Oguri N, Uotani Y, Takasakio T, Katayama K, Furusho H, Miyauchi M, Takahashi S, Hiyama T, Nakano Y
JACC Clin Electrophysiol. 2023; January; 9 (1); 43-53 (IF=7)
2. Regulation of osteogenesis in bone marrow-derived mesenchymal stem cells via histone deacetylase 1 and 2 co-cultured with human gingival fibroblasts and periodontal ligament cells.
Iwata T, Kaneda-Ikeda E, Takahashi K, Takeda K, Nagahara T, Kajiya M, Sasaki S, Ishida S, Yoshioka M, Matsuda S, Ouhara K, Fujita T, Kurihara H, Mizuno N
J Periodontal Res. 2023; February; 58 (1); 83-96 (IF=3.5)
3. Extracellular Release of Citrullinated Vimentin Directly Acts on Osteoclasts to Promote Bone Resorption in a Mouse Model of Periodontitis.
Shindo S, Pierrelus R, Ikeda A, Nakamura S, Heidari A, Pastore MR, Leon E, Ruiz S, Chheda H, Khatiwala R, Kumagai T, Tolson G, Elderbashy I, Ouhara K, Han X, Hernandez M, Vardar-Sengul S, Shiba H, Kawai T
Cells. 2023; April; 8;12(8); 1109 (IF=6)
4. In Situ Raman Analysis of Biofilm Exopolysaccharides Formed in Streptococcus mutans and Streptococcus sanguinis Commensal Cultures
Pezzotti G, Ofuji S, Imamura H, Adachi T, Yamamoto T, Kanamura N, Ohgitani E, Marin E, Zhu W, Mazda O, Togo A, Kimura S, Iwata T, Shiba H, Ouhara K, Aoki T, Kawai T
Int J Mol Sci. 2023; April; 3;24(7); 6694 (IF=5.6)
5. A Cartilaginous Construct with Bone Collar Exerts Bone-Regenerative Property Via Rapid Endochondral Ossification.
Morimoto S, Kajiya M, Yoshii H, Yoshino M, Horikoshi S, Motoike S, Iwata T, Ouhara K, Ando T, Yoshimoto T, Shintani T, Mizuno N
Stem Cell Reviews and Reports. 2023; May; 19 (6); 1812-1827 (IF=4.8)
6. Distinctive Biological Properties Between Mesenchymal Stem Cells Spheroids and Clumps of Mesenchymal Stem Cells/Extracellular Matrix Complexes in 3D Culture Systems
Yoshino M, Kajiya M, Yoshii H, Morimoto S, Horikoshi S, Tari M, Iwata T, Ouhara K, Ando T, Yoshimoto T, Shintani T, Mizuno N
Applied Sciences. 2023; November; 13 (23); 12790 (IF=2.7)
7. Relationship between CD4+ T-cell counts at baseline and initial periodontal treatment efficacy in patients undergoing treatment for HIV infection: A retrospective observational study Shintani T, Okada M, Iwata T, Kawagoe M, Yamasaki N, Inoue T, Nakanishi J, Furutama D, Takeda K, Ando T, Nakaoka M, Mizuno N, Fujii T, Kajiya M, Shiba H.
J Clin Periodontol. 2023; November; 50 (11); 1520-1529. (IF=6.7)
8. Periostin regulates integrin expression in gingival epithelial cells.
Hirata R, Iwata T, Fujita T, Nagahara T, Matsuda S, Sasaki S, Taniguchi Y, Hamamoto Y, Ouhara K, Kudo Y, Kurihara H, Mizuno N (IF=2.9)
J Oral Biosci. 2023; December; 2: S1349-0079(23)00190-1; Online ahead of print.
9. N-glycan in the variable region of monoclonal ACPA (CCP-Ab1) promotes the exacerbation of experimental arthritis.
Kawataka M, Ouhara K, Kobayashi E, Shinoda K, Tobe K, Fujimori R, Mizuno N, Sugiyama E, Ozawa T, Kishi H
Rheumatology (Oxford). 2023; December; 1;62(12); 3968-3977. (IF=5.5)
10. Mechanosignaling YAP/TAZ-TEAD axis regulates the immunomodulatory properties of mesenchymal stem cells.
Yoshii H, Kajiya K, Yoshino M, Morimoto S, Horikoshi S, Tari M, Motoike S, Iwata T, Ouhara K, Ando T, Yoshimoto T, Shintani T, Mizuno N
Stem Cell Reviews and Reports. 2023; November; Online ahead of print. (IF=4.8)
11. Increasing the Apical Sizes of Root Enlarged for Root Canal Obturation Influences the Outcome of Single-Root-Canal Teeth Affected by Apical Periodontitis
Hirata-Tsuchiya S, Furutama D, Saito-Nakayama N, Naruse T, Kawayanagi T, Nishihama S, Miyata A, Shirawachi S, Sadaoka N, Wang C, Yoshida K, Nakanishi J, Matsuda S, Takeda K, Shiba H
European Endodontic Journal. 2023; ahead of print (IF=1.8)

2022

1.　Cancellous bone-like tissue replacement from calcinosis patients with systemic sclerosis with multiple external root resorption.
Memida T, Matsuda S, Nakamoto T, Ouhara K, Kajiya M, Hirata S, Sugiyama E, Kakimoto N, Mizuno N.
Bone Rep. 2022; January; 16; 101165 (IF=2.5)
2. Cytokines regulate stemness of mesenchymal stem cells via miR-628-5p during periodontal regeneration.
Iwata T, Mizuno N, Nagahara T, Kaneda-Ikeda E, Kajiya M, Sasaki S, Takeda K, Kiyota M, Yagi R, Fujita T, Kurihara H.
J Periodontol. 2022; Februaly; 93(2); 269-286 (IF=4.3)
3. Comprehensive characterization of sortase A-dependent surface proteins in Streptococcus mutans.
Katsumata T, Nguyen-Tra Le M, Kawada-Matsuo M, Taniguchi Y, Ouhara K, Oogai Y, Nakata M, Mizuno N, Nishitani Y, Komatsuzawa H.
Microbiol Immunol. 2022; March; 66(3); 145-156 (IF=2.6)
4. Xenotransplantation of cryopreserved human clumps of mesenchymal stem cells/extracellular matrix complexes pretreated with IFN-γ induces rat calvarial bone regeneration.
Ogawa T, Kajiya M, Horikoshi S, Yoshii H, Yoshino M, Motoike S, Morimoto S, Sone H, Iwata T, Ouhara K, Matsuda S, Mizuno N.
Regen Ther. 2022; April; 20; 117-125 (IF=4.3)
5. Masticatory dysfunction in patients with diabetic neuropathy: A cross-sectional study
Hamamoto Y, Ouhara K, Miyagawa T, Shintani T, Komatsu N, Kajiya M, Matsuda S, Fujita T, Sasaki S, Iwata T, Ohno H, Yoneda M, Mizuno N, Kurihara H
PLoS One. 2022; June; 17(6); e0269594 (IF=3.7)
6. Induction of functional xeno-free MSCs from human iPSCs via a neural crest cell lineage
Kamiya D, Takenaka-Ninagawa N, Motoike S, Kajiya M, Akaboshi T, Zhao C, Shibata M, Senda S, Toyooka Y, Sakurai H, Kurihara H, Ikeya M
NPJ Regenerative Medicine 2022; September; 7(1); 47 (IF=7.2)
7. Clumps of mesenchymal stem cells/ extracellular matrix complexes directly reconstruct the functional periodontal tissue in a rat periodontal defect model
Sone H, Kajiya M, Takeda K, Sasaki S, Horikoshi S, Motoike S, Morimoto S, Yoshii H, Yoshino M, Iwata T, Ouhara K, Matsuda S, Mizuno N
J Tissue Eng Regen Med. 2022; October; 16(10); 945-955 (IF=3.3)
8. Regulation of osteogenesis in bone marrow-derived mesenchymal stem cells via histone deacetylase 1 and 2 co-cultured with human gingival fibroblasts and periodontal ligament cells
Iwata T, Kaneda-Ikeda E, Takahashi K, Takeda K, Nagahara T, Kajiya M, Sasaki S, Ishida S, Yoshioka M, Matsuda S, Ouhara K, Fujita T, Kurihara H, Mizuno N.
J Periodontal Res. 2022; November; Epub (IF=3.5)
9. The Lipopolysaccharide Mutant Re-LPS Is a Useful Tool for Detecting LPS Contamination in Rheumatoid Synovial Cell Cultures.
Kohno H, Ouhara K, Mokuda S, Tokunaga T, Sugimoto T, Watanabe H, Ishitoku M, Yoshida Y, Mizuno N, Ozawa T, Kawataka M, Hirata S, Kishi H, Sugiyama E.
Pathobiology. 2022; November; 89(2); 92-100 (IF=5)
10. Periapical lesion following Cnm-positive Streptococcus mutans pulp infection worsens cerebral hemorrhage onset in an SHRSP rat model
Taniguchi Y, Ouhara K, Kitagawa M, Akutagawa K, Kawada-Matsuo M, Tamura T, Zhai R, Hamamoto Y, Kajiya M, Matsuda S, Maruyama H, Komatsuzawa H, Shiba H, Mizuno N
Clinical and Experimental Immunology 2022; December; 210(3); 321-330 (IF=4.6)
11. Anti-Inflammatory Effects of Geniposidic Acid on Porphyromonas gingivalis-Induced Periodontitis in Mice
Tamura T, Zhai R, Takemura T, Ouhara K, Taniguchi Y, Hamamoto Y, Fujimori R, Kajiya M, Matsuda S, Munenaga S, Fujita T and Mizuno N
Biomedicines 2022; December; 10(12); 3096 (IF=4.7)

2021

1. Identification of regulatory mRNA and microRNA for differentiation into cementoblasts and periodontal ligament cells
Iwata T, Mizuno N, Nagahara T, Kaneda-Ikeda E, Kajiya M, Kitagawa M, Takeda K, Yoshioka M, Yagi R, Takata T, Kurihara H.
J Periodontal Res. 2021; January; 56(1); 69-82. (IF=3.5)
2. Periodontitis and the outcome of atrial fibrillation ablation: Porphyromonas gingivalis is related to atrial fibrillation recurrence.
Miyauchi S, Tokuyama T, Shintani T, Nishi H, Hamamoto Y, Ouhara K, Furusho H, Miyauchi M, Komatsuzawa H, Nakano Y.
J Cardiovasc Electrophysiol. 2021; May; ;32(5); 1240-1250. (IF=2.7)
3. Functional Regulatory Mechanisms Underlying Bone Marrow Mesenchymal Stem Cell Senescence During Cell Passages
Iwata T, Mizuno N, Ishida S, Kajiya M, Nagahara T, Kaneda-Ikeda E, Yoshioka M, Munenaga S, Ouhara K, Fujita T, Kawaguchi H, Kurihara H. Cell Biochem Biophys. 2021; June; 79(2); 321-336. (IF=2.6)
4. Selective and easy detection of the Porphyromonas gingivalis fimA type II and IV genes by loop-mediated isothermal amplification.
Kitagawa M, Ouhara K, Oka H, Sakamoto S, Yamane Y, Kashiwagi A, Kanamoto R, Miyauchi M, Nagamine K.
J Microbiol Methods. 2021; June; 185:00:00; 106228 (IF=2.2)
5. Involvement of Rac1 in macrophage activation by brain-derived neurotrophic factor.
Sasaki S, Takeda T, Ouhara K, Shirawachi S, Kajiya M, Matsuda S, Kono S, Shiba H, Kurihara H, Mizuno N
Mol Biol Rep. 2021; June; 48(6); 5249-5257 (IF=2.8)
6. The role of nuclear receptor 4A1 (NR4A1) in drug-induced gingival overgrowth
Saki Hatano, Shinji Matsuda, Ai Okanobu, Daisuke Furutama, Takumi Memida, Mikihito Kajiya, Kazuhisa Ouhara, Tsuyoshi Fujita, Noriyoshi Mizuno, Hidemi Kurihara
FASEB Journal. 2021; July; 7; e21693 (IF=4.8)
7. Cytokines regulate stemness of mesenchymal stem cells via miR-628-5p during periodontal regeneration
Iwata T, Mizuno N, Nagahara T, Kaneda-Ikeda E, Kajiya M, Sasaki S, Takeda K, Kiyota M, Yagi R, Fujita T, Kurihara H.
J Periodontol. 2021; July; JPER.21-0064; Epub 2021 Jul 21. (IF=4.3)
8. External cervical resorption detected via cone-beam computed tomography in a patient with myelin oligodendrocyte glycoprotein antibody-associated disease: A case report.
Munenaga S, Usuda M, Ouhara K, Maetani Y, Kajiya M, Matsuda S, Furusho H, Miyauchi M, Nakamori M, Maruyama H, Nishi H, Kawaguchi H.
Clin Case Rep. 2021; July; 6;9(7); e04415. (IF=0.7)
9. Generalized periodontitis treated with periodontal, orthodontic, and prosthodontic therapy: A case report
Masato Kaku, Shinji Matsuda, Takayasu Kubo, Saiji Shimoe, Kazuhiro Tsuga, Hidemi Kurihara, Kotaro Tanimoto
World J Clin Cases. 2021; July; 26;9(21); 6110-6124. (IF=1.1)
10. Clumps of Mesenchymal Stem Cells/Extracellular Matrix Complexes Generated with Xeno-Free Chondro-Inductive Medium Induce Bone Regeneration via Endochondral Ossification
Horikoshi S, Kajiya M, Motoike S, Yoshino M, Morimoto S, Yoshii H, Ogawa T, Sone H, Iwata T, Ouhara K, Matsuda S, Mizuno N, Kurihara H.
Biomedicine. 2021; October; 9(10); 1408 (IF=4.7)
11. Comprehensive characterization of sortase A-dependent surface proteins in Streptococcus mutans.
Katsumata T, Nguyen-Tra Le M, Kawada-Matsuo M, Taniguchi Y, Ouhara K, Oogai, Y, Nakata M, Mizuno N, Nishitani Y, Komatsuzawa H.
Microbiol Immunol. 2021; December. 10 (IF=2.6)

歯周病態学研究室の住所

Copyright © 2024 Department of Periodontal Medicine